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Human organ chips enable rapid drug repurposing for COVID-19

Human organ chips enable rapid drug repurposing for COVID-19

A Harvard University Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the institute’s organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19. The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the process … Continued

COVID-19 Transmission Risk Calculator

As we continue to navigate the COVID-19 pandemic, people around the world often ask themselves the same question as they head into various buildings and scenarios: What changes can we make to reduce the risk of COVID-19 transmission? To help provide some insight into this question, the Harvard Healthy Buildings Program has released this beta … Continued

NIH vaccine designer takes coronavirus research to Harvard

The U.S. government scientist who helped design one of the first COVID-19 vaccines and then tackled skepticism of the shots in communities of color is moving to Harvard in June. Kizzmekia Corbett of the National Institutes of Health will take her research into next-generation vaccines for coronaviruses to the Harvard T.H. Chan School of Public Health, … Continued

“The Brain Architects” Podcast: COVID-19 Special Edition: Creating Communities of Opportunity

In this third special COVID-19 episode of The Brain Architects podcast, host Sally Pfitzer is joined by Dr. David Williams, the Florence Sprague Norman and Laura Smart Norman Professor of Public Health, Harvard T.H. Chan School of Public Health. Dr. Williams discusses ways in which the coronavirus pandemic is particularly affecting people of color in … Continued

Why do some patients with COVID-19 die while others—who appear just as ill—survive? New research offers clues.

Harvard Medical School researchers at Massachusetts General Hospital have identified the protein “signature” of severe COVID-19, which they describe in a new study published in Cell Reports Medicine. “We were interested in asking whether we could identify mechanisms that might be contributing to death in COVID-19,” said Marcia Goldberg, HMS professor of medicine at Mass … Continued

Researchers identify protein ‘signature’ of severe COVID-19

Harvard Medical School researchers at Massachusetts General Hospital have identified the protein “signature” of severe COVID-19, which they describe in a new study published in Cell Reports Medicine… To undertake the study, the Mass General team used proteomics, the analysis of the entire protein composition, or proteome, of a cell, tissue, or organism. In this case, proteomic … Continued

Thinking About Racial Disparities in COVID-19 Impacts Through a Science-Informed, Early Childhood Lens

With COVID spread, ‘racism — not race — is the risk factor’

Harvard experts take a hard look at environmental inequities Faculty and researchers at Harvard and elsewhere agree that the disparity is a result of interrelated circumstances within the environments in which economically disadvantaged and minority populations live, reflecting systemic racism. The factors include aspects of the physical environment, such as greater exposure to pollution and … Continued

As COVID-19 vaccination rises, focus sharpens on pregnancy, children

Are children really spared the worst effects of COVID-19? What’s the likelihood that an expectant or new mother will pass SARS-CoV-2—or antibodies that protect against it—to her fetus through the placenta or to her infant through breastfeeding? Are COVID-19 vaccines as safe and effective for children as they are for adults? What about vaccination during pregnancy … Continued

Low Risk of Mom Passing COVID to Newborn

The risk of mother-to-newborn transmission of COVID-19 is low, but the illness in pregnant women can trigger preterm birth, researchers say. The new study looked at 255 babies born in Massachusetts last year to mothers with a recent positive test for COVID-19. Only about 2% of the 88% of babies who were tested for COVID-19 had a … Continued