COVID-19 and the global pandemic have caused significant disruption to all aspects of life including Alzheimer’s clinical research worldwide. The impact of COVID, quarantine, and the resulting fear and isolation are causing problems, but also driving unprecedented innovation. Yet the urgency to make scientific advances in Alzheimer’s and other dementia is so high that we must look at how we can safely resume, continue and even accelerate clinical research. The environment we are in is allowing us to establish creative and innovative ways to safely move some studies forward.