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New antiviral drug combination is highly effective against SARS-CoV-2

Researchers have identified a powerful combination of antivirals to treat COVID-19. Combining the drug brequniar with remdesivir or molnupiravir—both approved by the U.S. Food and Drug Administration for emergency use—inhibited the SARS-CoV-2 virus in human respiratory cells and in mice, according to a new study led by researchers in the Perelman School of Medicine and the University of Maryland School of Medicine.