Multisystem inflammatory syndrome (MIS) is the inflammation of various tissues and has been cited as a complication of SARS-CoV-2 infection. Originally identified in children, a form of MIS has since been described in adults (MIS-A). Giovanni Davogustto, MD, and colleagues at Vanderbilt University Medical Center identified and collected characteristics of adult patients at risk of MIS-A from electronic health records to better understand its presentation. Patients in the study were narrowed from the pool of patients testing positive for SARS-CoV-2 and separated from those experiencing acute COVID-19 infection.